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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RET
All Species:
9.09
Human Site:
S774
Identified Species:
18.18
UniProt:
P07949
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07949
NP_065681.1
1114
124319
S774
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
Chimpanzee
Pan troglodytes
XP_001171246
813
90715
K495
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
Rhesus Macaque
Macaca mulatta
XP_001090823
731
81824
K413
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
Dog
Lupus familis
XP_543915
1108
124018
S768
S
E
L
R
D
L
L
S
E
F
N
L
L
K
Q
Cat
Felis silvestris
Mouse
Mus musculus
P35546
1115
123855
S775
S
E
L
R
D
L
L
S
E
F
N
L
L
K
Q
Rat
Rattus norvegicus
Q04589
822
91806
K504
A
I
G
L
D
K
D
K
P
N
R
V
T
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507715
665
75620
Q347
K
L
Y
G
A
C
S
Q
D
G
P
L
Y
L
I
Chicken
Gallus gallus
P18461
823
92281
I505
V
M
A
E
A
V
G
I
D
K
D
R
P
K
E
Frog
Xenopus laevis
Q03364
813
91322
K495
A
E
A
L
G
I
D
K
E
R
P
K
E
S
V
Zebra Danio
Brachydanio rerio
Q8JG38
817
91370
I499
V
M
A
E
A
L
G
I
D
K
D
K
P
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q09147
1052
117795
G733
V
V
M
A
E
A
E
G
L
P
R
S
P
Q
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Q26614
972
110463
V654
E
G
A
F
G
K
V
V
I
G
E
A
V
G
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
28.4
27.9
86.4
N.A.
83.4
28.9
N.A.
43
27.5
28.1
27.7
N.A.
23.6
N.A.
N.A.
24
Protein Similarity:
100
42.2
41.5
92
N.A.
90.2
43
N.A.
50.5
43.5
42.3
42
N.A.
37.7
N.A.
N.A.
41.2
P-Site Identity:
100
20
20
93.3
N.A.
93.3
20
N.A.
0
6.6
13.3
13.3
N.A.
0
N.A.
N.A.
0
P-Site Similarity:
100
26.6
26.6
100
N.A.
100
26.6
N.A.
13.3
33.3
26.6
33.3
N.A.
20
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
0
34
9
25
9
0
0
0
0
0
9
0
0
0
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
50
0
34
0
25
0
17
0
0
0
0
% D
% Glu:
9
34
0
17
9
0
9
0
34
0
9
0
9
0
17
% E
% Phe:
0
0
0
9
0
0
0
0
0
25
0
0
0
0
0
% F
% Gly:
0
9
25
9
17
0
17
9
0
17
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
25
0
0
0
9
0
17
9
0
0
0
0
0
17
% I
% Lys:
9
0
0
0
0
34
0
34
0
17
0
17
0
67
0
% K
% Leu:
0
9
25
34
0
34
25
0
9
0
0
25
25
9
9
% L
% Met:
0
17
9
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
25
25
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
25
9
17
0
25
0
0
% P
% Gln:
0
0
0
0
0
0
0
9
0
0
0
0
0
9
25
% Q
% Arg:
0
0
0
25
0
0
0
0
0
9
34
9
0
0
0
% R
% Ser:
25
0
0
0
0
0
9
25
0
0
0
9
0
9
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
25
0
0
% T
% Val:
25
9
0
0
0
9
9
9
0
0
0
34
9
0
34
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
0
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _